de Kehtam’s “Fasiculus Medicine” first Anatomy Book with Illustrations, 1500.

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“For my part I deem those blessed to whom, by favour of the gods, it has been granted either to do what is worth writing of, or to write what is worth reading; above measure blessed those on whom both gifts have been conferred”–Pliny the Elder.
Johannes de Kehtam’s Fasciculus Medicine (printed in Venice in 1500) was the first anatomy to be printed with illustrations.
Ketham was described as a German doctor living in Italy and may well have been Johann von Kerchheim, a German practising surgery and medicine in Venice during 1470), and who wrote a series of tracts on various aspects of medicine which were then collected into this single bound volume.
6a00d83542d51e69e2017ee57542ac970dThe illustrations are spectacular and to me have a very modern sensibility in their mid-Renaissance woodcut legacy–the look very clear and concise, are well proportioned, nicely labelled, and give plenty of free rein to open and blank spaces on the woodblock.
The only time these images really “fail” is when they appear in colour–a process that would’ve been undertaken privately, by the purchaser of the book, who would have contracted with an artisan to colo r the book.
The images in almost all of the cases of colouring that I have seen just do not match the elegance and brilliance of the original with no color.
Source for all images: NATIONAL LIBRARY OF MEDICINE,
Read on further via JF Ptak Science Books: First Printed & Illustrated Medical Book (1500)

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